Somatostatin and somatostatin analogues reduce PDGF-induced endometrial cell proliferation and motility.

  title={Somatostatin and somatostatin analogues reduce PDGF-induced endometrial cell proliferation and motility.},
  author={Marta Annunziata and Ra{\'u}l M Luque and Mario Duran-Prado and Alessandra Baragli and Cristina Grande and Marco Volante and Manuel D Gahete and Francesco Deltetto and Marco Camanni and Ezio Ghigo and Justo P Casta{\~n}o and Riccarda Granata},
  journal={Human reproduction},
  volume={27 7},
BACKGROUND Endometriosis is characterized by ectopic implantation of endometrial cells, which show increased proliferation and migration. Somatostatin (SST) and its analogues inhibit normal and cancer cell growth and motility through the SST receptors, sst1-5. Cortistatin (CST), which displays high structural and functional homology with SST, binds all ssts, as well as MrgX2. Our objective was to investigate the gene expression of the SST/CST system and to determine the effect of SST and its… CONTINUE READING


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