Somatosensory cortical map changes following digit amputation in adult monkeys

@article{Merzenich1984SomatosensoryCM,
  title={Somatosensory cortical map changes following digit amputation in adult monkeys},
  author={Michael Merzenich and Randall Nelson and Michael P. Stryker and Max S. Cynader and Axel Schoppmann and John M. Zook},
  journal={Journal of Comparative Neurology},
  year={1984},
  volume={224}
}
The cortical representations of the hand in area 3b in adult owl monkeys were defined with use of microelectrode mapping techniques 2-8 months after surgical amputation of digit 3, or of both digits 2 and 3. [] Key Method Digital nerves were tied to prevent their regeneration within the amputation stump. Successive maps were derived in several monkeys to determine the nature of changes in map organization in the same individuals over time. In all monkeys studied, the representations of adjacent digits and…
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1,335 Citations

Plasticity of the somatosensory cortical map in macaque monkeys after chronic partial amputation of a digit

TLDR
The hyperinnervation of remaining skin may have reactivated neurons of the somatosensory system silenced by the amputation, leading to the recovery of a cortical map but with a modified organization.

Spatial acuity after digit amputation.

TLDR
The cortical expansion that is presumed to accompany digit amputation had no effect on tactile pattern recognition performance, and more detailed analyses of specific confusion patterns and of the improvement with practice showed no significant differences.

Immediate and chronic changes in responses of somatosensory cortex in adult flying-fox after digit amputation

TLDR
This work has followed the changes in response in the primary somatosensory cortex in the flying-fox following amputation of the single exposed digit on the forelimb and found that neurons in the area of cortex receiving inputs from the missing digit were not silent but responded to stimulation of adjoining regions of the digit, hand, arm and wing.

Short-term expansion of receptive fields in rat primary somatosensory cortex after hindpaw digit denervation

Functional changes at periphery and cortex following dorsal root lesions in adult monkeys

TLDR
The results demonstrate peripherally mediated central reorganization in young adult macaque monkeys by selectively removing cutaneous input from the index finger and thumb by lesioning dorsal rootlets to examine both immediate and long-term systemic responses to this deficit.

Progression of change following median nerve section in the cortical representation of the hand in areas 3b and 1 in adult owl and squirrel monkeys

Neuronal response properties within subregions of raccoon somatosensory cortex 1 week after digit amputation.

TLDR
Multiple penetrations in the somatosensory cortex of three anesthetized raccoons 1 week following amputation of the fourth digit provided detailed information about somatotopy and neuronal responsiveness in the deafferented cortex, indicating plasticity within the core region of the raccoon requires more extensive changes via polysynaptic pathways.

Unexpected reorganization of somatosensory cortex in a raccoon with extensive forelimb loss

Functional reorganization of primary somatosensory cortex in adult owl monkeys after behaviorally controlled tactile stimulation.

TLDR
These experiments demonstrate that functional cortical remodeling of the S1 koniocortical field, area 3b, results from behavioral manipulations in normal adult owl monkeys.

Large-scale reorganization at multiple levels of the somatosensory pathway follows therapeutic amputation of the hand in monkeys

  • S. FlorenceJ. Kaas
  • Biology, Psychology
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1995
TLDR
Evidence is provided that much of the large-scale cortical reorganization that occurs after a major loss of peripheral inputs reflects the sprouting or expansion of afferents from the remaining forelimb into deprived territories of the spinal cord and brainstem.
...

References

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Progression of change following median nerve section in the cortical representation of the hand in areas 3b and 1 in adult owl and squirrel monkeys

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TLDR
The organization of part of the primary somatosensory cortex was examined in anesthetized raccoons at 2, 8, or 16 weeks after the normal peripheral input to this region of cortex had been removed by amputation of the fifth digit, suggestive of extensive anatomical changes either within the cortex itself or at subcortical levels.

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TLDR
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TLDR
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