Somatosensory cortical map changes following digit amputation in adult monkeys

@article{Merzenich1984SomatosensoryCM,
  title={Somatosensory cortical map changes following digit amputation in adult monkeys},
  author={Michael Merzenich and Randall Nelson and Michael P. Stryker and Max S. Cynader and Axel Schoppmann and John M. Zook},
  journal={Journal of Comparative Neurology},
  year={1984},
  volume={224}
}
The cortical representations of the hand in area 3b in adult owl monkeys were defined with use of microelectrode mapping techniques 2-8 months after surgical amputation of digit 3, or of both digits 2 and 3. [] Key Method Digital nerves were tied to prevent their regeneration within the amputation stump. Successive maps were derived in several monkeys to determine the nature of changes in map organization in the same individuals over time. In all monkeys studied, the representations of adjacent digits and…
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The hyperinnervation of remaining skin may have reactivated neurons of the somatosensory system silenced by the amputation, leading to the recovery of a cortical map but with a modified organization.
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TLDR
The cortical expansion that is presumed to accompany digit amputation had no effect on tactile pattern recognition performance, and more detailed analyses of specific confusion patterns and of the improvement with practice showed no significant differences.
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TLDR
This work has followed the changes in response in the primary somatosensory cortex in the flying-fox following amputation of the single exposed digit on the forelimb and found that neurons in the area of cortex receiving inputs from the missing digit were not silent but responded to stimulation of adjoining regions of the digit, hand, arm and wing.
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TLDR
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Reorganization of Somatosensory Cortex After Nerve and Spinal Cord Injury.
  • N. Jain, S. Florence, J. Kaas
  • Biology, Medicine
    News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society
  • 1998
TLDR
Somatotopic maps in the mature brain reorganize in response to deafferentation by peripheral nerve cut, amputations, or spinal lesions, and an understanding of these mechanisms could guide interventions that potentiate recovery from such injuries.
Neuronal response properties within subregions of raccoon somatosensory cortex 1 week after digit amputation.
TLDR
Multiple penetrations in the somatosensory cortex of three anesthetized raccoons 1 week following amputation of the fourth digit provided detailed information about somatotopy and neuronal responsiveness in the deafferented cortex, indicating plasticity within the core region of the raccoon requires more extensive changes via polysynaptic pathways.
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References

SHOWING 1-10 OF 58 REFERENCES
Reorganization of raccoon somatosensory cortex following removal of the fifth digit
TLDR
The organization of part of the primary somatosensory cortex was examined in anesthetized raccoons at 2, 8, or 16 weeks after the normal peripheral input to this region of cortex had been removed by amputation of the fifth digit, suggestive of extensive anatomical changes either within the cortex itself or at subcortical levels.
Modular segregation of functional cell classes within the postcentral somatosensory cortex of monkeys.
The distribution of two functionally distinct cell types, presumably related to slowly and rapidly adapting mechanoreceptors in the skin, was explored within the representation of the glabrous hand
Cell changes in sensory ganglia following proximal and disal nerve section in the monkey
Ganglion cell changes were studied in 25 monkeys following systematic section of spinal and cranial sensory nerves proximal or distal to the ganglion. Ganglion cells were studied in Nissl
Formation of New Connexions in Adult Rat Brains after Partial Deafferentation
Mapping of the receptive fields of cells in the thalamus and cortex after section of the dorsal columns in the rat reveals evidence of functional reorganization in the central nervous system.
Connections of areas 3b and 1 of the parietal somatosensory strip with the ventroposterior nucleus in the owl monkey (Aotus trivirgatus)
TLDR
In injections of HRP combined with the anterograde tracer, 3H‐proline, indicate that VP neurons are reciprocally interconnected with both Areas 3b and 1, and it appears that some neurons in VP project to both cortical representations.
Magnification, receptive-field area, and "hypercolumn" size in areas 3b and 1 of somatosensory cortex in owl monkeys.
TLDR
The area of cortex presumed to receive all fibers from any given receptive field was obtained and found to be independent of the body surface represented and may be akin to the “hypercolumn” proposed for primary visual cortex.
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