Somatosensory cortical map changes following digit amputation in adult monkeys

@article{Merzenich1984SomatosensoryCM,
  title={Somatosensory cortical map changes following digit amputation in adult monkeys},
  author={Michael Merzenich and Randall Nelson and Michael P. Stryker and Max S. Cynader and Axel Schoppmann and John M. Zook},
  journal={Journal of Comparative Neurology},
  year={1984},
  volume={224}
}
The cortical representations of the hand in area 3b in adult owl monkeys were defined with use of microelectrode mapping techniques 2-8 months after surgical amputation of digit 3, or of both digits 2 and 3. [] Key Method Digital nerves were tied to prevent their regeneration within the amputation stump. Successive maps were derived in several monkeys to determine the nature of changes in map organization in the same individuals over time. In all monkeys studied, the representations of adjacent digits and…
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1,344 Citations

Plasticity of the somatosensory cortical map in macaque monkeys after chronic partial amputation of a digit

The hyperinnervation of remaining skin may have reactivated neurons of the somatosensory system silenced by the amputation, leading to the recovery of a cortical map but with a modified organization.

Spatial acuity after digit amputation.

The cortical expansion that is presumed to accompany digit amputation had no effect on tactile pattern recognition performance, and more detailed analyses of specific confusion patterns and of the improvement with practice showed no significant differences.

Immediate and chronic changes in responses of somatosensory cortex in adult flying-fox after digit amputation

This work has followed the changes in response in the primary somatosensory cortex in the flying-fox following amputation of the single exposed digit on the forelimb and found that neurons in the area of cortex receiving inputs from the missing digit were not silent but responded to stimulation of adjoining regions of the digit, hand, arm and wing.

Short-term expansion of receptive fields in rat primary somatosensory cortex after hindpaw digit denervation

Functional changes at periphery and cortex following dorsal root lesions in adult monkeys

The results demonstrate peripherally mediated central reorganization in young adult macaque monkeys by selectively removing cutaneous input from the index finger and thumb by lesioning dorsal rootlets to examine both immediate and long-term systemic responses to this deficit.

Progression of change following median nerve section in the cortical representation of the hand in areas 3b and 1 in adult owl and squirrel monkeys

Reorganization of Somatosensory Cortex After Nerve and Spinal Cord Injury.

  • N. JainS. FlorenceJ. Kaas
  • Biology, Medicine
    News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society
  • 1998
Somatotopic maps in the mature brain reorganize in response to deafferentation by peripheral nerve cut, amputations, or spinal lesions, and an understanding of these mechanisms could guide interventions that potentiate recovery from such injuries.

Neocortical representational dynamics in adult primates: Implications for neuropsychology

Neuronal response properties within subregions of raccoon somatosensory cortex 1 week after digit amputation.

Multiple penetrations in the somatosensory cortex of three anesthetized raccoons 1 week following amputation of the fourth digit provided detailed information about somatotopy and neuronal responsiveness in the deafferented cortex, indicating plasticity within the core region of the raccoon requires more extensive changes via polysynaptic pathways.

Unexpected reorganization of somatosensory cortex in a raccoon with extensive forelimb loss

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References

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