Somatosensory cortical map changes following digit amputation in adult monkeys

  title={Somatosensory cortical map changes following digit amputation in adult monkeys},
  author={Michael Merzenich and Randall Nelson and Michael P. Stryker and Max S. Cynader and Axel Schoppmann and John M. Zook},
  journal={Journal of Comparative Neurology},
The cortical representations of the hand in area 3b in adult owl monkeys were defined with use of microelectrode mapping techniques 2-8 months after surgical amputation of digit 3, or of both digits 2 and 3. [] Key Method Digital nerves were tied to prevent their regeneration within the amputation stump. Successive maps were derived in several monkeys to determine the nature of changes in map organization in the same individuals over time. In all monkeys studied, the representations of adjacent digits and…

Plasticity of the somatosensory cortical map in macaque monkeys after chronic partial amputation of a digit

The hyperinnervation of remaining skin may have reactivated neurons of the somatosensory system silenced by the amputation, leading to the recovery of a cortical map but with a modified organization.

Spatial acuity after digit amputation.

The cortical expansion that is presumed to accompany digit amputation had no effect on tactile pattern recognition performance, and more detailed analyses of specific confusion patterns and of the improvement with practice showed no significant differences.

Immediate and chronic changes in responses of somatosensory cortex in adult flying-fox after digit amputation

This work has followed the changes in response in the primary somatosensory cortex in the flying-fox following amputation of the single exposed digit on the forelimb and found that neurons in the area of cortex receiving inputs from the missing digit were not silent but responded to stimulation of adjoining regions of the digit, hand, arm and wing.

Functional changes at periphery and cortex following dorsal root lesions in adult monkeys

The results demonstrate peripherally mediated central reorganization in young adult macaque monkeys by selectively removing cutaneous input from the index finger and thumb by lesioning dorsal rootlets to examine both immediate and long-term systemic responses to this deficit.

Neuronal response properties within subregions of raccoon somatosensory cortex 1 week after digit amputation.

Multiple penetrations in the somatosensory cortex of three anesthetized raccoons 1 week following amputation of the fourth digit provided detailed information about somatotopy and neuronal responsiveness in the deafferented cortex, indicating plasticity within the core region of the raccoon requires more extensive changes via polysynaptic pathways.

Functional reorganization of primary somatosensory cortex in adult owl monkeys after behaviorally controlled tactile stimulation.

These experiments demonstrate that functional cortical remodeling of the S1 koniocortical field, area 3b, results from behavioral manipulations in normal adult owl monkeys.

Large-scale reorganization at multiple levels of the somatosensory pathway follows therapeutic amputation of the hand in monkeys

  • S. FlorenceJ. Kaas
  • Biology, Psychology
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1995
Evidence is provided that much of the large-scale cortical reorganization that occurs after a major loss of peripheral inputs reflects the sprouting or expansion of afferents from the remaining forelimb into deprived territories of the spinal cord and brainstem.



Reorganization of raccoon somatosensory cortex following removal of the fifth digit

The organization of part of the primary somatosensory cortex was examined in anesthetized raccoons at 2, 8, or 16 weeks after the normal peripheral input to this region of cortex had been removed by amputation of the fifth digit, suggestive of extensive anatomical changes either within the cortex itself or at subcortical levels.

Cell changes in sensory ganglia following proximal and disal nerve section in the monkey

Ganglion cell changes were studied in 25 monkeys following systematic section of spinal and cranial sensory nerves proximal or distal to the ganglion. Ganglion cells were studied in Nissl

Formation of New Connexions in Adult Rat Brains after Partial Deafferentation

Mapping of the receptive fields of cells in the thalamus and cortex after section of the dorsal columns in the rat reveals evidence of functional reorganization in the central nervous system.

Magnification, receptive-field area, and "hypercolumn" size in areas 3b and 1 of somatosensory cortex in owl monkeys.

The area of cortex presumed to receive all fibers from any given receptive field was obtained and found to be independent of the body surface represented and may be akin to the “hypercolumn” proposed for primary visual cortex.

Representations of the body surface in postcentral parietal cortex of Macaca fascicularis

The somatotopic organization of the postcentral parietal cortex of the Old World monkey, Macaca fascicularis, was determined with multi‐unit microelectrode recordings and it is suggested that the representation in Area 3b is homologous to “SmI” (or “SI”) in non‐primates.

Double representation of the body surface within cytoarchitectonic area 3b and 1 in “SI” in the owl monkey (aotus trivirgatus)

Microelectrode multiunit mapping studies of parietal cortex in owl monkeys indicate that the classical “primary” somatosensory region (or “SI”) including the separate architectonic fields 3a, 3b, 1,