Somatosensory cortical map changes following digit amputation in adult monkeys

@article{Merzenich1984SomatosensoryCM,
  title={Somatosensory cortical map changes following digit amputation in adult monkeys},
  author={Michael Merzenich and Randall Nelson and Michael P. Stryker and Max S. Cynader and Axel Schoppmann and John M. Zook},
  journal={Journal of Comparative Neurology},
  year={1984},
  volume={224}
}
The cortical representations of the hand in area 3b in adult owl monkeys were defined with use of microelectrode mapping techniques 2-8 months after surgical amputation of digit 3, or of both digits 2 and 3. [] Key Method Digital nerves were tied to prevent their regeneration within the amputation stump. Successive maps were derived in several monkeys to determine the nature of changes in map organization in the same individuals over time. In all monkeys studied, the representations of adjacent digits and…

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TLDR
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TLDR
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Neuronal response properties within subregions of raccoon somatosensory cortex 1 week after digit amputation.

TLDR
Multiple penetrations in the somatosensory cortex of three anesthetized raccoons 1 week following amputation of the fourth digit provided detailed information about somatotopy and neuronal responsiveness in the deafferented cortex, indicating plasticity within the core region of the raccoon requires more extensive changes via polysynaptic pathways.

Functional reorganization of primary somatosensory cortex in adult owl monkeys after behaviorally controlled tactile stimulation.

TLDR
These experiments demonstrate that functional cortical remodeling of the S1 koniocortical field, area 3b, results from behavioral manipulations in normal adult owl monkeys.

Large-scale reorganization at multiple levels of the somatosensory pathway follows therapeutic amputation of the hand in monkeys

  • S. FlorenceJ. Kaas
  • Biology, Psychology
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1995
TLDR
Evidence is provided that much of the large-scale cortical reorganization that occurs after a major loss of peripheral inputs reflects the sprouting or expansion of afferents from the remaining forelimb into deprived territories of the spinal cord and brainstem.
...

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