Somatosensory activation of two fingers can be discriminated with ultrahigh-density diffuse optical tomography

@article{Habermehl2012SomatosensoryAO,
  title={Somatosensory activation of two fingers can be discriminated with ultrahigh-density diffuse optical tomography},
  author={Christina Habermehl and Susanne Holtze and Jens Steinbrink and Stefan P. Koch and Hellmuth Obrig and Jan Mehnert and Christoph H. Schmitz},
  journal={NeuroImage},
  year={2012},
  volume={59},
  pages={3201-3211}
}
Topographic non-invasive near infrared spectroscopy (NIRS) has become a well-established tool for functional brain imaging. Applying up to 100 optodes over the head of a subject, allows achieving a spatial resolution in the centimeter range. This resolution is poor compared to other functional imaging tools. However, recently it was shown that diffuse optical tomography (DOT) as an extension of NIRS based on high-density (HD) probe arrays and supplemented by an advanced image reconstruction… Expand
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References

SHOWING 1-10 OF 60 REFERENCES
Phase-encoded retinotopy as an evaluation of diffuse optical neuroimaging
TLDR
Improvements in spatial resolution and signal-to-noise, afforded by recently developed high-density diffuse optical tomography approaches, now permit detailed phase-encoded mapping of the visual cortex's retinotopic organization, a significant advancement in the level of detail that can be obtained from non-invasive optical imaging of functional brain responses. Expand
Retinotopic mapping of adult human visual cortex with high-density diffuse optical tomography
TLDR
A high-performance, high-density diffuse optical tomography (DOT) system that overcomes previous limitations and enables superior image quality and the utility of the DOT system is shown by presenting functional hemodynamic maps of the adult human visual cortex. Expand
Quantitative evaluation of high-density diffuse optical tomography: in vivo resolution and mapping performance.
TLDR
It is demonstrated that HD-DOT enables detailed phase-encoded retinotopic mapping, while sparse arrays are limited to imaging individual block-design visual stimuli and that these improvements provide a substantial advancement in neuroimaging capability. Expand
Brain Specificity of Diffuse Optical Imaging: Improvements from Superficial Signal Regression and Tomography
TLDR
Improvements in signal quality and reproducibility are assessed due to these methods using a well-characterized visual paradigm and the high-density DOT system, with greater improvements when the approaches are used together. Expand
Diffuse optical imaging of the whole head.
TLDR
Whole-head optical measurements, in addition to providing maps of multiple brain regions' responses to brain activation, will enable better understandings of the physiological signals, ultimately leading to better signal processing algorithms to distinguish physiological signal clutter from brain activation signals. Expand
Mapping human somatosensory cortex in individual subjects with 7T functional MRI.
TLDR
The increased blood-oxygen-level-dependent contrast-to-noise ratio at ultra-high field (7 Tesla) is used to measure the topographic representation of the digits in human somatosensory cortex at 1 mm isotropic resolution in individual subjects to allow somatotopic fMRI to be used toMeasure the representation of digits in patients undergoing rehabilitation or plastic changes after peripheral nerve damage as well as tracking changes in normal subjects undergoing perceptual learning. Expand
Optimizing the mapping of finger areas in primary somatosensory cortex using functional MRI.
TLDR
The precise computer-controlled stimulus, together with data acquisition at high spatial resolution and with only minor smoothing during evaluation, could be a very useful strategy in studies of brain plasticity and rehabilitation strategies in hand and finger disorders and injuries. Expand
Depth sensitivity and image reconstruction analysis of dense imaging arrays for mapping brain function with diffuse optical tomography.
TLDR
The imaging sensitivity available within the brain (including depths beyond superficial cortical gyri) is quantified as a function of increasing the maximum source-detector separation included in the data. Expand
Finger representations in human primary somatosensory cortex as revealed by high-resolution functional MRI of tactile stimulation
TLDR
Fine-scale functional organization of the finger areas in the human primary somatosensory cortex was investigated by high-resolution BOLD MRI at 3 T using a multi-echo FLASH sequence with a voxel size of 2 mm(3) for the identification of individual variations in finger somatotopy. Expand
Hemodynamic evoked response of the sensorimotor cortex measured noninvasively with near-infrared optical imaging.
TLDR
The findings based on optical imaging are in agreement with results in the literature obtained with positron emission tomography and functional magnetic resonance imaging. Expand
...
1
2
3
4
5
...