Somatomedin C as tentative pathogenic factor in neurofibromatosis.

  title={Somatomedin C as tentative pathogenic factor in neurofibromatosis.},
  author={Hans A. Hansson and Claes G. K. Lauritzen and Clas Lossing and Karin M Petruson},
  journal={Scandinavian journal of plastic and reconstructive surgery and hand surgery},
  volume={22 1},
The distribution of somatomedin C (Sm-C; insulin-like growth factor I; IGF-I) immunoreactivity was examined in biopsies from three patients having the diagnosis neurofibromatosis established on clinical and histopathological criteria. All biopsies showed increased Sm-C immunoreactivity limited to areas with neurofibromas. Schwann cells, adjacent spindle-shaped fibroblast-like cells and newly formed blood vessels were positive. In addition, Sm-C immunoreactivity could be demonstrated in cells in… CONTINUE READING