Somatogenic and lactogenic activity of the recombinant 22 kDa isoform of human placental growth hormone.

@article{Igout1995SomatogenicAL,
  title={Somatogenic and lactogenic activity of the recombinant 22 kDa isoform of human placental growth hormone.},
  author={Ahmed Igout and F E Frankenne and Mireille L'hermite-Bal{\'e}riaux and Ana Mart{\'i}n and Georges P Hennen},
  journal={Growth regulation},
  year={1995},
  volume={5 1},
  pages={60-5}
}
During pregnancy, the human placenta secretes a variant of pituitary growth hormone (hGH-V) differing in sequence from the pituitary growth hormone (hGH-N) by 13 amino acids substitutions. HGH-V replaces hGH-N in the maternal bloodstream during the second half of pregnancy. HGH-V is produced in two, possibly three, isoforms: a 22 kDa form, a glycosylated 25 kDa form, and a probable 26 kDa form resulting from alternative splicing of the mRNA. Here we have studied the somatogenic and lactogenic… CONTINUE READING

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