Somatodendritic Kv7/KCNQ/M channels control interspike interval in hippocampal interneurons.

@article{Lawrence2006SomatodendriticKC,
  title={Somatodendritic Kv7/KCNQ/M channels control interspike interval in hippocampal interneurons.},
  author={Jeffery J Lawrence and Fernanda Saraga and Joseph F Churchill and Jeffrey M Statland and Katherine E. Travis and Frances K. Skinner and Chris J McBain},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2006},
  volume={26 47},
  pages={
          12325-38
        }
}
The M-current (I(M)), comprised of Kv7 channels, is a voltage-activated K+ conductance that plays a key role in the control of cell excitability. In hippocampal principal cells, I(M) controls action potential (AP) accommodation and contributes to the medium-duration afterhyperpolarization, but the role of I(M) in control of interneuron excitability remains unclear. Here, we investigated I(M) in hippocampal stratum oriens (SO) interneurons, both from wild-type and transgenic mice in which green… CONTINUE READING

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