Somatic tetraploidy in specific chick retinal ganglion cells induced by nerve growth factor.

@article{Morillo2010SomaticTI,
  title={Somatic tetraploidy in specific chick retinal ganglion cells induced by nerve growth factor.},
  author={S Marielba Morillo and Pedro Escoll and Antonio de la Hera and Jose Frade},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 1},
  pages={
          109-14
        }
}
A subset of neurons in the normal vertebrate nervous system contains double the normal amount of DNA in their nuclei. These neurons are all thought to derive from aberrant mitoses in neuronal precursor cells. Here we show that endogenous NGF induces DNA replication in a subpopulation of differentiating chick retinal ganglion cells that express both the neurotrophin receptor p75 and the E2F1 transcription factor, but that lack the retinoblastoma protein. Many of these neurons avoid G2/M… CONTINUE READING

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