Somatic stem cells and the kinetics of mutagenesis and carcinogenesis.

  title={Somatic stem cells and the kinetics of mutagenesis and carcinogenesis.},
  author={John Cairns},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={99 16},
  • John Cairns
  • Published 2002 in
    Proceedings of the National Academy of Sciences…
There is now strong experimental evidence that epithelial stem cells arrange their sister chromatids at mitosis such that the same template DNA strands stay together through successive divisions; DNA labeled with tritiated thymidine in infancy is still present in the stem cells of adult mice even though these cells are incorporating (and later losing) bromodeoxyuridine [Potten, C. S., Owen, G., Booth, D. & Booth, C. (2002) J. Cell Sci.115, 2381-2388]. But a cell that preserves "immortal strands… CONTINUE READING

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