Somatic recombination rather than uniparental disomy suggested as another mechanism by which genetic imprinting may play a role in the etiology of Prader-Willi syndrome

@article{Gregory1991SomaticRR,
  title={Somatic recombination rather than uniparental disomy suggested as another mechanism by which genetic imprinting may play a role in the etiology of Prader-Willi syndrome},
  author={Cassie A Gregory and J D Schwartz and A. J. Kirkilionis and Nancy Rudd and John L. Hamerton},
  journal={Human Genetics},
  year={1991},
  volume={88},
  pages={42-48}
}
Six Prader-Willi syndrome (PWS) patients with normal karyotypes and their parents were analyzed to determine the nature of the molecular aberrations present in the proximal region of 15q and to determine the parental origin of the aberrant chromosome 15. In addition, the likehood that uniparental disomy plays a significant role in the etiology of PWS… CONTINUE READING