Somatic point mutations occurring early in development: a monozygotic twin study

@article{Li2013SomaticPM,
  title={Somatic point mutations occurring early in development: a monozygotic twin study},
  author={Rui Li and Alexandre Montpetit and Maryl{\`e}ne Rousseau and Si-Yu Wu and Celia M. T. Greenwood and Tim D. Spector and Michael N. Pollak and Constantin Polychronakos and J. Brent Richards},
  journal={Journal of Medical Genetics},
  year={2013},
  volume={51},
  pages={28 - 34}
}
The identification of somatic driver mutations in cancer has enabled therapeutic advances by identifying drug targets critical to disease causation. However, such genomic discoveries in oncology have not translated into advances for non-cancerous disease since point mutations in a single cell would be unlikely to cause non-malignant disease. An exception to this would occur if the mutation happened early enough in development to be present in a large percentage of a tissue's cellular population… Expand
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