Somatic pharmacogenomics in cancer

@article{Ikediobi2008SomaticPI,
  title={Somatic pharmacogenomics in cancer},
  author={Ogechi N Ikediobi},
  journal={The Pharmacogenomics Journal},
  year={2008},
  volume={8},
  pages={305-314}
}
Many of the initial examples of the clinical utility of pharmacogenetics were elucidated in the field of oncology. Those examples were largely based on the existence of germline genetic variation that influences the metabolism of cytotoxic drugs. However, with the development of kinase inhibitors, drugs designed to preferentially target altered proteins driving oncogenesis, pharmacogenetics in cancer has shifted to understanding the somatic differences that determine response to these targeted… CONTINUE READING
BETA
Highly Cited
This paper has 30 citations. REVIEW CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 120 REFERENCES

Similar Papers

Loading similar papers…