Somatic p53 mutations in human breast carcinomas in an Icelandic population: a prognostic factor.

@article{Thorlacius1993SomaticPM,
  title={Somatic p53 mutations in human breast carcinomas in an Icelandic population: a prognostic factor.},
  author={Steinunn Thorlacius and A L B{\"o}rresen and J{\'o}runn Erla Eyfj{\"o}rd},
  journal={Cancer research},
  year={1993},
  volume={53 7},
  pages={
          1637-41
        }
}
Mutations in the p53 gene are among the most common genetic changes in human carcinomas. They have been found in many tumor types including colon, lung, and breast. We have used constant denaturant gel electrophoresis in order to screen samples from 109 breast carcinomas for mutations in four conserved regions, exons 5, 7, and 8, of the p53 gene. Samples were also analyzed for allelic loss of the p53 gene and of markers more distal on chromosome 17 p. Mutations were confirmed by DNA sequencing… CONTINUE READING

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