Somatic origin of T-cell epitopes within antibody variable regions: significance to monoclonal therapy and genesis of systemic autoimmune disease.

@article{Wysocki1998SomaticOO,
  title={Somatic origin of T-cell epitopes within antibody variable regions: significance to monoclonal therapy and genesis of systemic autoimmune disease.},
  author={Lawrence J Wysocki and Xiaoli Zhang and Diana S. Smith and Christopher M Snyder and Cristina B. C. Bonorino},
  journal={Immunological reviews},
  year={1998},
  volume={162},
  pages={233-46}
}
During an immune response, specific antibody variable region genes are diversified by a somatic point mutation process that generates de novo "foreign" V-region sequences. This creates an interesting problem in immune regulation because B cells are highly proficient at self-presenting V-region peptides in the context of class II MHC. Though our studies… CONTINUE READING