Somatic neurofibromatosis type 1 (NF1) inactivation characterizes NF1-associated pilocytic astrocytoma.

@article{Gutmann2013SomaticNT,
  title={Somatic neurofibromatosis type 1 (NF1) inactivation characterizes NF1-associated pilocytic astrocytoma.},
  author={David H Gutmann and Michael D. McLellan and Ibrahim Hussain and John W. Wallis and Lucinda L. Fulton and Robert S. Fulton and Vincent Magrini and Ryan T. Demeter and Todd Wylie and Cyriac Kandoth and Jeffrey Russell Leonard and Abhijit Guha and Christopher A Miller and Li Ding and Elaine R. Mardis},
  journal={Genome research},
  year={2013},
  volume={23 3},
  pages={431-9}
}
Low-grade brain tumors (pilocytic astrocytomas) arising in the neurofibromatosis type 1 (NF1) inherited cancer predisposition syndrome are hypothesized to result from a combination of germline and acquired somatic NF1 tumor suppressor gene mutations. However, genetically engineered mice (GEM) in which mono-allelic germline Nf1 gene loss is coupled with bi… CONTINUE READING