Somatic mutations throughout the entire mitochondrial genome are associated with elevated PSA levels in prostate cancer patients.


The genetic etiology of prostate cancer, the most common form of male cancer in western countries, is complex and the interplay of disease genes with environmental factors is far from being understood. Studies on somatic mitochondrial DNA (mtDNA) mutations have become an important aspect of cancer research because these mutations might have functional… (More)
DOI: 10.1016/j.ajhg.2010.11.001