Somatic mutations throughout the entire mitochondrial genome are associated with elevated PSA levels in prostate cancer patients.

@article{KlossBrandsttter2010SomaticMT,
  title={Somatic mutations throughout the entire mitochondrial genome are associated with elevated PSA levels in prostate cancer patients.},
  author={Anita Kloss-Brandst{\"a}tter and Georg Sch{\"a}fer and Gertraud Erhart and Alexander H{\"u}ttenhofer and Stefan Coassin and Christof Seifarth and Monika Summerer and Jasmin Bektic and Helmut Klocker and Florian Kronenberg},
  journal={American journal of human genetics},
  year={2010},
  volume={87 6},
  pages={802-12}
}
The genetic etiology of prostate cancer, the most common form of male cancer in western countries, is complex and the interplay of disease genes with environmental factors is far from being understood. Studies on somatic mitochondrial DNA (mtDNA) mutations have become an important aspect of cancer research because these mutations might have functional consequences and/or might serve as biosensors for tumor detection and progression. We sequenced the entire mitochondrial genome (16,569 bp) from… CONTINUE READING
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