Somatic mutations of the ERBB4 kinase domain in human cancers.

  title={Somatic mutations of the ERBB4 kinase domain in human cancers.},
  author={Young Hwa Soung and Jong Woo Lee and Su Young Kim and Young Wang and Keon Hyun Jo and Seok Whan Moon and Won Sang Park and Suk Woo Nam and Jung Young Lee and Nam Jin Yoo and Sug Hyung Lee},
  journal={International journal of cancer},
  volume={118 6},
The EGFR family consists of 4 receptor tyrosine kinases, EGFR (ERBB1), ERBB2 (HER2), ERBB3 (HER3) and ERBB4 (HER4). Recent reports revealed that the kinase domains of both EGFR (ERBB1) and ERBB2 gene were somatically mutated in human cancers, raising the possibility that the other ERBB members possess somatic mutations in human cancers. Here, we performed mutational analysis of the ERBB4 kinase domain by polymerase chain reaction-single-strand conformation polymorphism assay in 595 cancer… CONTINUE READING
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