Somatic mutations of epidermal growth factor receptor in bile duct and gallbladder carcinoma.

@article{Leone2006SomaticMO,
  title={Somatic mutations of epidermal growth factor receptor in bile duct and gallbladder carcinoma.},
  author={Francesco Leone and Giuliana Cavalloni and Ymera Pignochino and Ivana Sarotto and Renato Ferraris and Wanda Piacibello and Tiziana Venesio and Lorenzo Capussotti and Mauro Risio and Massimo Aglietta},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2006},
  volume={12 6},
  pages={
          1680-5
        }
}
OBJECTIVE Conventional therapies are still unsuccessful in patients with carcinoma arising from the biliary tract. Somatic mutations of the epidermal growth factor receptor (EGFR) gene and the activation of its downstream pathways predict the sensitivity to small-molecule inhibitors in non-small cell lung carcinoma. Therefore, we analyzed EGFR mutations and related pathways in gallbladder and bile duct carcinomas to consider the possible application of these alternative therapeutic strategies… CONTINUE READING

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