Somatic mutations in the tyrosine kinase domain of epidermal growth factor receptor (EGFR) abrogate EGFR-mediated radioprotection in non-small cell lung carcinoma.

@article{Das2007SomaticMI,
  title={Somatic mutations in the tyrosine kinase domain of epidermal growth factor receptor (EGFR) abrogate EGFR-mediated radioprotection in non-small cell lung carcinoma.},
  author={Amit Das and Benjamin P. C. Chen and Michael D. Story and Mitsuo Sato and John D. Minna and David J. Chen and Chaitanya S. Nirodi},
  journal={Cancer research},
  year={2007},
  volume={67 11},
  pages={5267-74}
}
The epidermal growth factor receptor (EGFR) is an important determinant of radioresponse, whose elevated expression and activity frequently correlates with radioresistance in several cancers, including non-small cell lung carcinoma (NSCLC). We reported recently that NSCLC cell lines harboring somatic, activating mutations in the tyrosine kinase domain (TKD) of the EGFR exhibit significant delays in the repair of DNA double-strand breaks (DSB) and poor clonogenic survival in response to… CONTINUE READING

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