Somatic mutations in the mitochondria of rheumatoid arthritis synoviocytes

  title={Somatic mutations in the mitochondria of rheumatoid arthritis synoviocytes},
  author={Tanya R. Da Sylva and Alison M Connor and Yvonne Mburu and Edward Clark Keystone and Gillian Wu},
  journal={Arthritis Research & Therapy},
  pages={R844 - R851}
Somatic mutations have a role in the pathogenesis of a number of diseases, particularly cancers. Here we present data supporting a role of mitochondrial somatic mutations in an autoimmune disease, rheumatoid arthritis (RA). RA is a complex, multifactorial disease with a number of predisposition traits, including major histocompatibility complex (MHC) type and early bacterial infection in the joint. Somatic mutations in mitochondrial peptides displayed by MHCs may be recognized as non-self… CONTINUE READING
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