Somatic mutations in the BRCA2 gene and high frequency of allelic loss of BRCA2 in sporadic male breast cancer.

@article{Kwiatkowska2002SomaticMI,
  title={Somatic mutations in the BRCA2 gene and high frequency of allelic loss of BRCA2 in sporadic male breast cancer.},
  author={Eliza P. Kwiatkowska and Marek Teresiak and Danuta Brȩborowicz and Andrzej Mackiewicz},
  journal={International journal of cancer},
  year={2002},
  volume={98 6},
  pages={943-5}
}
Breast cancer occurs rarely in men and risk factors for the disease include germline mutations of the BRCA2 gene. High frequency of allelic loss at the BRCA2 locus has been reported in sporadic breast tumors, but somatic mutations of BRCA2 are very rare. Here we report the first case of somatic BRCA2 mutation in male breast cancer with demonstrated loss of heterozygosity. We analyzed a series of 27 archival samples from male breast cancer patients for BRCA2 mutations and loss of heterozygosity… CONTINUE READING
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