Somatic mutations in the BRCA1 gene in Chinese sporadic breast and ovarian cancer

@article{Khoo1999SomaticMI,
  title={Somatic mutations in the BRCA1 gene in Chinese sporadic breast and ovarian cancer},
  author={U Y Khoo and Hilmi Ozçelik and Annie Nga-Yin Cheung and Louis Wing-Cheong Chow and Hextan Yuen-Sheung Ngan and Susan J Done and Anthony C. T. Liang and Vivian WY Chan and Gordon K H Au and Wing-Fung Ng and Cycles SP Poon and Yuet-Foon Leung and Florence Loong and Philip Ip and Gavin SW Chan and Irene L Andrulis and Jing Hua Lu and F. S. Ho},
  journal={Oncogene},
  year={1999},
  volume={18},
  pages={4643-4646}
}
Inherited mutations in the BRCA1 gene confer increased susceptibility to breast and ovarian cancer. Its role in sporadic carcinogenesis is not well defined. Somatic mutations in breast cancers have not been reported and to date there are only three reports of somatic mutations in sporadic ovarian cancers. To investigate the contribution of BRCA1 mutations to sporadic breast and ovarian cancer in the Chinese population, we analysed 62 samples from Chinese women using the protein truncation test… CONTINUE READING

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