Somatic mutations at the trinucleotide repeats of androgen receptor gene in male hepatocellular carcinoma

@article{Yeh2007SomaticMA,
  title={Somatic mutations at the trinucleotide repeats of androgen receptor gene in male hepatocellular carcinoma},
  author={S. Yeh and C. Chiu and C. Chen and S. Lu and H. Hsu and D. Chen and P. Chen},
  journal={International Journal of Cancer},
  year={2007},
  volume={120}
}
Androgen and androgen receptor (AR) have long been implicated in liver carcinogenesis, especially for the male dominance feature. However, whether AR gene could occur in somatic mutations that might contribute to this process has not yet been studied. DNA sequencing and genotyping were conducted for detecting the genetic aberrations of AR gene in 257 primary hepatocellular carcinomas (HCCs) and also the dysplastic nodules (DN) from another 11 patients. Twenty‐one AR somatic mutations causing… Expand
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References

SHOWING 1-10 OF 58 REFERENCES
Androgen Receptor Mutations in High-Grade Prostate Cancer before Hormonal Therapy
  • 41
  • PDF
Androgen receptor variants with short glutamine or glycine repeats may identify unique subpopulations of men with prostate cancer.
  • 201
  • PDF
Androgen receptor mutations in prostate cancer.
  • 273
The androgen receptor gene mutations database (ARDB): 2004 update
  • 300
  • PDF
Microsatellite mutation (CAG24-->18) in the androgen receptor gene in human prostate cancer.
  • 166
Androgen-receptor gene CAG repeats, plasma testosterone levels, and risk of hepatitis B-related hepatocellular carcinoma.
  • 123
  • PDF
...
1
2
3
4
5
...