Somatic mutations at the trinucleotide repeats of androgen receptor gene in male hepatocellular carcinoma

@article{Yeh2007SomaticMA,
  title={Somatic mutations at the trinucleotide repeats of androgen receptor gene in male hepatocellular carcinoma},
  author={S. Yeh and C. Chiu and C. Chen and S. Lu and H. Hsu and D. Chen and P. Chen},
  journal={International Journal of Cancer},
  year={2007},
  volume={120}
}
Androgen and androgen receptor (AR) have long been implicated in liver carcinogenesis, especially for the male dominance feature. However, whether AR gene could occur in somatic mutations that might contribute to this process has not yet been studied. DNA sequencing and genotyping were conducted for detecting the genetic aberrations of AR gene in 257 primary hepatocellular carcinomas (HCCs) and also the dysplastic nodules (DN) from another 11 patients. Twenty‐one AR somatic mutations causing… Expand
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Possible involvement of androgen receptor alterations in hepatocarcinogenesis.
  • M. Barone, M. Margiotta, +7 authors A. Francavilla
  • Biology, Medicine
  • Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
  • 2009
  • 9
RETRACTED ARTICLE: Association of androgen receptor exon 1 CAG repeat length with risk of hepatocellular carcinoma: a case–control study
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Androgen receptor is a new potential therapeutic target for the treatment of hepatocellular carcinoma.
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Prediction of deleterious functional effects of non-synonymous single nucleotide polymorphisms in human nuclear receptor genes using a bioinformatics approach.
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Androgen receptor signaling in hepatocellular carcinoma and pancreatic cancers.
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Cell cycle-related kinase is a direct androgen receptor-regulated gene that drives β-catenin/T cell factor-dependent hepatocarcinogenesis.
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Genomics of Hepatocellular Carcinoma
Androgen receptor CAG repeat length contraction in diseased and non-diseased prostatic tissues
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