Somatic mutations at the trinucleotide repeats of androgen receptor gene in male hepatocellular carcinoma

  title={Somatic mutations at the trinucleotide repeats of androgen receptor gene in male hepatocellular carcinoma},
  author={Shiou-Hwei Yeh and C. Chiu and C. Chen and S. Lu and H. Hsu and D. Chen and P. Chen},
  journal={International Journal of Cancer},
  • Shiou-Hwei Yeh, C. Chiu, +4 authors P. Chen
  • Published 2007
  • Biology, Medicine
  • International Journal of Cancer
  • Androgen and androgen receptor (AR) have long been implicated in liver carcinogenesis, especially for the male dominance feature. However, whether AR gene could occur in somatic mutations that might contribute to this process has not yet been studied. DNA sequencing and genotyping were conducted for detecting the genetic aberrations of AR gene in 257 primary hepatocellular carcinomas (HCCs) and also the dysplastic nodules (DN) from another 11 patients. Twenty‐one AR somatic mutations causing… CONTINUE READING
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