Somatic mutation. From the dark zone to the light.

@article{Maclennan1994SomaticMF,
  title={Somatic mutation. From the dark zone to the light.},
  author={I. C. M. Maclennan},
  journal={Current biology : CB},
  year={1994},
  volume={4 1},
  pages={70-2}
}
The affinity maturation of antibodies that occurs during immune responses to protein antigens involves site-directed hypermutation of immunoglobulin variable-region genes that is activated in germinal centres. 

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