Somatic mutation rates scale with lifespan across mammals

@article{Cagan2021SomaticMR,
  title={Somatic mutation rates scale with lifespan across mammals},
  author={Alex Cagan and Adrian Baez-Ortega and Natalia Brzozowska and Federico Abascal and Tim H. H. Coorens and Mathijs Arnoud Sanders and Andrew R. J. Lawson and Luke M. R. Harvey and Shriram Bhosle and David C. Jones and Raul E Alcantara and Timothy M. Butler and Yvette Hooks and Kirsty Roberts and Elizabeth Anderson and Sharna Lunn and Edmund J Flach and Simon Spiro and Inez Sukuna Januszczak and Ethan Wrigglesworth and Hannah Jenkins and Tilly Dallas and Nic J. Masters and Matthew W. Perkins and Robert Deaville and Megan Druce and Ruzhica Bogeska and Michael D. Milsom and Bj{\"o}rn Neumann and F Gorman and Fernando Constantino‐Casas and Laura E. Peachey and Diana Bochynska and Ewan St. John Smith and Moritz Gerstung and Peter J. Campbell and Elizabeth P. Murchison and Michael R. Stratton and I{\~n}igo Martincorena},
  journal={Nature},
  year={2021},
  volume={604},
  pages={517 - 524}
}
The rates and patterns of somatic mutation in normal tissues are largely unknown outside of humans. Comparative analyses can shed light on the diversity of mutagenesis across species and on long-standing hypotheses regarding the evolution of somatic mutation rates and their role in cancer and ageing. Here, we used whole-genome sequencing of 208 intestinal crypts from 56 individuals to study the landscape of somatic mutation across 16 mammalian species. We found somatic mutagenesis to be… 
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