Somatic mutation of TSSC5, a novel imprinted gene from human chromosome 11p15.5.

@article{Lee1998SomaticMO,
  title={Somatic mutation of TSSC5, a novel imprinted gene from human chromosome 11p15.5.},
  author={Min-goo Lee and Cynthia Reeves and Anna Schmitt and Kui Su and Timothy D. Connors and Rong Hu and Sheri Brandenburg and Michael J. Y. Lee and Glenn Miller and Andrew P. Feinberg},
  journal={Cancer research},
  year={1998},
  volume={58 18},
  pages={4155-9}
}
We previously reported the isolation of a 2.5 Mb tumor-suppressing subchromosomal transferable fragment (STF) from 11p15.5 and the identification of nine known genes and four novel genes within this STF. We now report the isolation of a fifth novel cDNA, tumor-suppressing STF cDNA 5, designated TSSC5, located within the STF. TSSC5 encodes a predicted protein of 424 amino acids. Sequence analysis suggests that TSSC5 is a membrane protein with 10 transmembrane segments, and it is located between… CONTINUE READING