Somatic mutation leads to efficient affinity maturation when centrocytes recycle back to centroblasts.

@article{Oprea1997SomaticML,
  title={Somatic mutation leads to efficient affinity maturation when centrocytes recycle back to centroblasts.},
  author={Mihaela Oprea and Alan S. Perelson},
  journal={Journal of immunology},
  year={1997},
  volume={158 11},
  pages={5155-62}
}
Although most mutations are deleterious, an interplay between somatic mutation and selection within germinal centers (GC) results in rapid generation of high affinity memory B cells. How high affinity B cells with large numbers of mutations are generated and preserved within GC containing at their peak only a few thousand cells has been puzzling. We have developed a model of somatic mutation and B cell expansion within a GC that resolves this puzzle. We show that the frequent recycling of Ag… CONTINUE READING

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References

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Showing 1-10 of 35 references

and F

  • J. C. Moor
  • H. Arnold.
  • 1996

and I

  • M. Casamayor-Palleja, J. Feuillard, J. Ball, M. Drew
  • C. M. MacLennan.
  • 1996

and T

  • E. Kallberg, S. Jainandunsing, D. Gray
  • Leanderson.
  • 1996

O

  • G. Grouard
  • de Bouteiller, J. Banchereau, and Y.-J. Liu.
  • 1995

and A

  • T. B. Keple
  • S. Perelson.
  • 1995

and G

  • S. Han, B. Zheng, J. Dal Porto
  • Kelsoe.
  • 1995

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