Somatic mutation in cancer and normal cells

@article{Martincorena2015SomaticMI,
  title={Somatic mutation in cancer and normal cells},
  author={I. Martincorena and P. Campbell},
  journal={Science},
  year={2015},
  volume={349},
  pages={1483 - 1489}
}
Spontaneously occurring mutations accumulate in somatic cells throughout a person’s lifetime. The majority of these mutations do not have a noticeable effect, but some can alter key cellular functions. Early somatic mutations can cause developmental disorders, whereas the progressive accumulation of mutations throughout life can lead to cancer and contribute to aging. Genome sequencing has revolutionized our understanding of somatic mutation in cancer, providing a detailed view of the… Expand
Detecting Somatic Mutations in Normal Cells.
The somatic mutation landscape of the human body
Single-cell whole-genome sequencing reveals the functional landscape of somatic mutations in B lymphocytes across the human lifespan
Tracing single-cell histories
Defining the impact of mutation accumulation on replicative lifespan in yeast using cancer-associated mutator phenotypes
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 61 REFERENCES
Signatures of mutational processes in human cancer
Punctuated Evolution of Prostate Cancer Genomes
The mutation rate and cancer.
...
1
2
3
4
5
...