Somatic mutation analysis of EGFR, KRAS, BRAF and PIK3CA in 861 patients with non-small cell lung cancer.

@article{Xu2011SomaticMA,
  title={Somatic mutation analysis of EGFR, KRAS, BRAF and PIK3CA in 861 patients with non-small cell lung cancer.},
  author={Jianping Xu and Jiaying He and Huiyi Yang and Xiaodi Luo and Zhangmin Liang and JiaXin Chen and Zhiping Cai and Jiasen Xu and Lifen Ren-Heidenreich},
  journal={Cancer biomarkers : section A of Disease markers},
  year={2011},
  volume={10 2},
  pages={63-9}
}
The prevalence of EGFR, KRAS, BRAF and PIK3CA somatic mutations in 861 randomly selected Chinese patients with non-small cell lung cancer (NSCLC) was assayed by the SurPlex®-xTAG70plex platform and analyzed. The results showed that the occurrence rates were 41.0, 8.0, 0.7 and 3.7%, respectively. The mutation rates significantly correlated with gender, histology and smoking history. The EGFR exon 19, 20 and 21 mutations were higher in females compared to males (p< 0.001, exon 19 and 21; p=0.018… CONTINUE READING

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