Somatic mutation analysis in melanoma using targeted next generation sequencing.

Abstract

Advanced stage malignant melanoma often responds poorly to therapy with low survival rates. New therapeutic approaches are based upon a growing understanding of the underlying molecular abnormalities. We demonstrate the feasibility of a next generation sequencing (NGS) assay, which targets hotspots in 50 cancer genes, to assess genotypes that may influence… (More)
DOI: 10.1016/j.yexmp.2017.08.006

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