Somatic mutagenesis in satellite cells associates with human skeletal muscle aging

@inproceedings{Franco2018SomaticMI,
  title={Somatic mutagenesis in satellite cells associates with human skeletal muscle aging},
  author={Irene Franco and Anna C V Johansson and Karl Sigvard Olsson and Peter Vrta{\vc}nik and P{\"a}r Lundin and Hafdis Th. Helgadottir and Malin Larsson and Gwladys Rev{\^e}chon and Carla Bosia and Andrea Pagnani and Paolo Provero and Thomas Gustafsson and Helene Fischer and Maria Eriksson},
  booktitle={Nature Communications},
  year={2018}
}
Human aging is associated with a decline in skeletal muscle (SkM) function and a reduction in the number and activity of satellite cells (SCs), the resident stem cells. To study the connection between SC aging and muscle impairment, we analyze the whole genome of single SC clones of the leg muscle vastus lateralis from healthy individuals of different ages (21–78 years). We find an accumulation rate of 13 somatic mutations per genome per year, consistent with proliferation of SCs in the healthy… CONTINUE READING
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