Somatic mtDNA mutations and aging--facts and fancies.

  title={Somatic mtDNA mutations and aging--facts and fancies.},
  author={Alexandra Kukat and Aleksandra Trifunovic},
  journal={Experimental gerontology},
  volume={44 1-2},
Mitochondria play a critical role in the life of the cell as they control their metabolic rate, energy production and cell death. Mitochondria have long been appreciated as causative to aging. The age-associated respiratory chain deficiency is typically unevenly distributed and affects only a subset of cells in various human tissues, such as heart, skeletal muscle, colonic crypts and neurons. Studies of mtDNA mutator mice has provided the first direct evidence that accelerating the mtDNA… CONTINUE READING