Somatic mosaicism for chromosome X and Y aneuploidies in monozygotic twins heterozygous for sickle cell disease mutation.

@article{Razzaghian2010SomaticMF,
  title={Somatic mosaicism for chromosome X and Y aneuploidies in monozygotic twins heterozygous for sickle cell disease mutation.},
  author={Hamid Reza Razzaghian and Mehdi H Shahi and Lars A Forsberg and Teresita D{\'i}az de St{\aa}hl and Devin M Absher and Niklas Dahl and Maxwell P. Westerman and Jan P. Dumanski},
  journal={American journal of medical genetics. Part A},
  year={2010},
  volume={152A 10},
  pages={2595-8}
}
Somatic genetic variation in health and disease is poorly explored. Monozygotic (MZ) twins are a suitable model for studies of somatic mosaicism since genetic differences in twins derived from the same zygote represent an irrefutable example of somatic variation. We report the analysis of a pair of generally healthy female MZ twins, discordant for somatic mosaicism for aneuploidy of chromosomes X and Y. Both twins are heterozygous carriers of sickle cell disease mutation. Genotyping of blood… CONTINUE READING
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