Somatic microindels: analysis in mouse soma and comparison with the human germline

@article{Gonzalez2007SomaticMA,
  title={Somatic microindels: analysis in mouse soma and comparison with the human germline},
  author={Kelly DF Gonzalez and Kathleen A. Hill and Kai Li and Wenyan Li and William A. Scaringe and Jicheng Wang and Dongqing Gu and Steve S. Sommer},
  journal={Human Mutation},
  year={2007},
  volume={28}
}
Microindels, defined as mutations that result in a colocalized microinsertion and microdeletion with a net gain or loss of between 1 and 50 nucleotides, may be an important contributor to cancer. We report the first comprehensive analysis of somatic microindels. Our large database of mutations in the lacI transgene of Big Blue® mice contains 0.5% microindels, 2.8% pure microinsertions, and 11.5% pure microdeletions. There appears to be no age, gender, or tissue‐type specificity in the frequency… 
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