Somatic microindels: analysis in mouse soma and comparison with the human germline

  title={Somatic microindels: analysis in mouse soma and comparison with the human germline},
  author={K. Gonzalez and K. Hill and K. Li and W. Li and W. Scaringe and Ji-cheng Wang and D. Gu and S. Sommer},
  journal={Human Mutation},
  • K. Gonzalez, K. Hill, +5 authors S. Sommer
  • Published 2007
  • Biology, Medicine
  • Human Mutation
  • Microindels, defined as mutations that result in a colocalized microinsertion and microdeletion with a net gain or loss of between 1 and 50 nucleotides, may be an important contributor to cancer. We report the first comprehensive analysis of somatic microindels. Our large database of mutations in the lacI transgene of Big Blue® mice contains 0.5% microindels, 2.8% pure microinsertions, and 11.5% pure microdeletions. There appears to be no age, gender, or tissue‐type specificity in the frequency… CONTINUE READING
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