Somatic hypermutation of immunoglobulin kappa transgenes: association of mutability with demethylation.

Abstract

Following antigen encounter, immunoglobulin genes are diversified by somatic hypermutation. The mechanism by which this mutational process preferentially targets immunoglobulin genes is not known, but is likely linked to transcription. However, transcription is not sufficient to ensure mutability. Here, by polymerase chain reaction amplification of… (More)

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@article{Jolly2001SomaticHO, title={Somatic hypermutation of immunoglobulin kappa transgenes: association of mutability with demethylation.}, author={Caroline Jolly and Michael S. Neuberger}, journal={Immunology and cell biology}, year={2001}, volume={79 1}, pages={18-22} }