Somatic hypermutation of immunoglobulin genes in human neonates.

  title={Somatic hypermutation of immunoglobulin genes in human neonates.},
  author={Jim Ridings and Ian C. Nicholson and W Sean Goldsworthy and Richard P. Haslam and D. M. V. Roberton and Heddy Zola},
  journal={Clinical and experimental immunology},
  volume={108 2},
The antibody response in the young infant is limited in several ways; in particular, responses generally are of low affinity and restricted to IgM. This raises the question whether the affinity maturation process, consisting of somatic mutation of immunoglobulin genes coupled with selection of high-affinity variants, is operative in the neonate. Re-arranged V(H)6 genes were amplified by polymerase chain reaction (PCR) from cord blood and from peripheral blood of infants. Heteroduplex analysis… CONTINUE READING