Somatic hypermutation of immunoglobulin and non-immunoglobulin genes.

  title={Somatic hypermutation of immunoglobulin and non-immunoglobulin genes.},
  author={Ursula Storb and Hong Ming Shen and Nancy Michael and Nayun Kim},
  journal={Philosophical transactions of the Royal Society of London. Series B, Biological sciences},
  volume={356 1405},
Somatic hypermutation (SHM) of immunoglobulin (Ig) genes is a highly specific mechanism restricted to B lymphocytes during only a few cell generations. Data presented here suggest that transcription of the target genes is required, but not sufficient for SHM. Presumably, cis-acting elements, such as those present in the Ig enhancers, are required to target a mutator factor (MuF) to Ig and human BCL-6 genes. It is postulated that the MuF travels with the transcribing RNA polymerase and is… CONTINUE READING

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