Somatic hypermutation in immunity and cancer: Critical analysis of strand-biased and codon-context mutation signatures.

@article{Steele2016SomaticHI,
  title={Somatic hypermutation in immunity and cancer: Critical analysis of strand-biased and codon-context mutation signatures.},
  author={E J Steele},
  journal={DNA repair},
  year={2016},
  volume={45},
  pages={1-24}
}
For 30 years two general mechanisms have competed to explain somatic hypermutation of immunoglobulin (Ig) genes. The first, the DNA-based model, is focused only on DNA substrates. The modern form is the Neuberger "DNA Deamination Model" based on activation-induced cytidine deaminase (AID) and short-patch error-prone DNA repair by DNA Polymerase-η operating around AID C-to-U lesions. The other is an RNA-based mechanism or the "Reverse Transcriptase Model" of SHM which produces strand-biased… CONTINUE READING