Somatic genetic changes in human breast cancer.

  title={Somatic genetic changes in human breast cancer.},
  author={Peter Devilee and Cees J. Cornelisse},
  journal={Biochimica et biophysica acta},
  volume={1198 2-3},
Quantitative imbalance in chromosomal material relative to the normal diploid situation is the most conspicuous genetic change in breast tumors, affecting virtually all chromosomes in varying frequencies. This imbalance is reflected by deviant DNA stemlines observed in DNA flow cytometry analysis, by numerical chromosome abnormalities in karyotype analysis and by loss of heterozygosity in DNA polymorphism studies. Gene amplification might be caused by the same genetic mechanisms that cause… CONTINUE READING
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