Somatic gene transfer of NGF to the aged brain: behavioral and morphological amelioration.

Abstract

Primary fibroblasts modified to secrete nerve growth factor (NGF) were implanted into the nucleus basalis magnocellularis (NBM) of aged memory impaired rats. The NGF-producing fibroblasts survived for 6 weeks following transplantation and continued expressing NGF mRNA through the duration of the experiment. A significant amelioration of the memory… (More)

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@article{Chen1995SomaticGT, title={Somatic gene transfer of NGF to the aged brain: behavioral and morphological amelioration.}, author={K. S. Chen and F. H. Gage}, journal={The Journal of neuroscience : the official journal of the Society for Neuroscience}, year={1995}, volume={15 4}, pages={2819-25} }