Somatic excision demonstrates that c-Jun induces cellular migration and invasion through induction of stem cell factor.

@article{Katiyar2007SomaticED,
  title={Somatic excision demonstrates that c-Jun induces cellular migration and invasion through induction of stem cell factor.},
  author={Sanjay K. Katiyar and Xuanmao Jiao and Erwin F Wagner and Michael Phillip Lisanti and Richard G. Pestell},
  journal={Molecular and cellular biology},
  year={2007},
  volume={27 4},
  pages={1356-69}
}
Cancer cells arise through sequential acquisition of mutations in tumor suppressors and oncogenes. c-Jun, a critical component of the AP-1 complex, is frequently overexpressed in diverse tumor types and has been implicated in promoting cellular proliferation, migration, and angiogenesis. Functional analysis of candidate genetic targets using germ line deletion in murine models can be compromised through compensatory mechanisms. As germ line deletion of c-jun induces embryonic lethality, somatic… CONTINUE READING
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