Somatic events unmask recessive cancer genes to initiate malignancy.

  title={Somatic events unmask recessive cancer genes to initiate malignancy.},
  author={Brenda L. Gallie and Ronald G. Worton},
  journal={Journal of cellular biochemistry},
  volume={32 3},
A heritable mutation predisposes an individual to certain childhood malignancies, such as retinoblastoma and Wilms' tumor. The chromosomal locations of the genes responsible for the predisposition are known by linkage with chromosomal deletions and enzyme markers. A study of these tumors in comparison to the normal constitutional cells of the patients, using enzyme and DNA markers near the predisposing genes, has shown that these genes are recessive to normal wild-type alleles at the cellular… CONTINUE READING