Somatic diversification of variable lymphocyte receptors in the agnathan sea lamprey

  title={Somatic diversification of variable lymphocyte receptors in the agnathan sea lamprey},
  author={Zeev Pancer and Chris T Amemiya and G{\"o}tz R A Ehrhardt and Jill Ceitlin and G. Larry Gartland and Max D. Cooper},
Although jawless vertebrates are apparently capable of adaptive immune responses, they have not been found to possess the recombinatorial antigen receptors shared by all jawed vertebrates. Our search for the phylogenetic roots of adaptive immunity in the lamprey has instead identified a new type of variable lymphocyte receptors (VLRs) composed of highly diverse leucine-rich repeats (LRR) sandwiched between amino- and carboxy-terminal LRRs. An invariant stalk region tethers the VLRs to the cell… CONTINUE READING
Highly Influential
This paper has highly influenced 16 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Recent Discussions
This paper has been referenced on Twitter 7 times over the past 90 days. VIEW TWEETS
231 Citations
50 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 231 extracted citations


Publications referenced by this paper.
Showing 1-10 of 50 references

an overview

  • Beutler, B. Innate immunity
  • Mol. Immunol. 40, 845–859
  • 2004

Genomic analysis of immunity in a urochordate and the emergence of the vertebrate immune system : “ waiting for Godot ”

  • K. Azumi
  • Immunogenetics
  • 2003

Identification and characterization of a TAP-family gene in the lamprey

  • Uinuk-Ool, S T.
  • Immunogenetics 55,
  • 2003

Similar Papers

Loading similar papers…