Somatic diversification of variable lymphocyte receptors in the agnathan sea lamprey

@article{Pancer2004SomaticDO,
  title={Somatic diversification of variable lymphocyte receptors in the agnathan sea lamprey},
  author={Z. Pancer and C. Amemiya and G. R. Ehrhardt and Jill Ceitlin and G. Gartland and M. Cooper},
  journal={Nature},
  year={2004},
  volume={430},
  pages={174-180}
}
  • Z. Pancer, C. Amemiya, +3 authors M. Cooper
  • Published 2004
  • Biology, Medicine
  • Nature
  • Although jawless vertebrates are apparently capable of adaptive immune responses, they have not been found to possess the recombinatorial antigen receptors shared by all jawed vertebrates. Our search for the phylogenetic roots of adaptive immunity in the lamprey has instead identified a new type of variable lymphocyte receptors (VLRs) composed of highly diverse leucine-rich repeats (LRR) sandwiched between amino- and carboxy-terminal LRRs. An invariant stalk region tethers the VLRs to the cell… CONTINUE READING
    576 Citations
    Variable lymphocyte receptors in hagfish.
    • Z. Pancer, N. R. Saha, +4 authors M. Cooper
    • Biology, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 2005
    • 190
    • PDF
    Organization of lamprey variable lymphocyte receptor C locus and repertoire development
    • 36
    • PDF
    Dual Nature of the Adaptive Immune System in Lampreys
    • 282
    Déjà vu: the identity of a third lineage of lymphocytes in lampreys
    • M. Kasahara
    • Biology, Medicine
    • Immunology and cell biology
    • 2013
    • 7
    Selection of the lamprey VLRC antigen receptor repertoire
    • 22
    • PDF
    Antigen-receptor genes of the agnathan lamprey are assembled by a process involving copy choice
    • 140
    VLR-based adaptive immunity.
    • 185

    References

    SHOWING 1-10 OF 56 REFERENCES
    Evolution of antigen binding receptors.
    • 316
    • PDF
    Lamprey lymphocyte-like cells express homologs of genes involved in immunologically relevant activities of mammalian lymphocytes
    • 141
    • PDF
    Isolation and characterization of lymphocyte-like cells from a lamprey
    • 134
    • PDF
    Identification of Two Ikaros‐like Transcription Factors in Lamprey
    • 37
    Do lampreys have lymphocytes? The Spi evidence.
    • S. Shintani, J. Terzic, +4 authors J. Klein
    • Biology, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 2000
    • 82
    • PDF
    Evolution of hematopoiesis: Three members of the PU.1 transcription factor family in a cartilaginous fish, Raja eglanteria.
    • 50
    • PDF
    The architecture of variant surface glycoprotein gene expression sites in Trypanosoma brucei.
    • 106
    • PDF