Somatic diversification of variable lymphocyte receptors in the agnathan sea lamprey

@article{Pancer2004SomaticDO,
  title={Somatic diversification of variable lymphocyte receptors in the agnathan sea lamprey},
  author={Zeev Pancer and Chris T Amemiya and G{\"o}tz R A Ehrhardt and Jill Ceitlin and G. Larry Gartland and Max D. Cooper},
  journal={Nature},
  year={2004},
  volume={430},
  pages={174-180}
}
Although jawless vertebrates are apparently capable of adaptive immune responses, they have not been found to possess the recombinatorial antigen receptors shared by all jawed vertebrates. Our search for the phylogenetic roots of adaptive immunity in the lamprey has instead identified a new type of variable lymphocyte receptors (VLRs) composed of highly diverse leucine-rich repeats (LRR) sandwiched between amino- and carboxy-terminal LRRs. An invariant stalk region tethers the VLRs to the cell… CONTINUE READING
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