Somatic action potentials are sufficient for late-phase LTP-related cell signaling.

@article{Dudek2002SomaticAP,
  title={Somatic action potentials are sufficient for late-phase LTP-related cell signaling.},
  author={Serena M Dudek and R. Douglas Fields},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2002},
  volume={99 6},
  pages={3962-7}
}
A question of critical importance confronting neuroscientists today is how biochemical signals initiated at a synapse are conveyed to the nucleus. This problem is particularly relevant to the generation of the late phases of long-term potentiation (LTP). Here we provide evidence that some signaling pathways previously associated with late-LTP can be activated in hippocampal CA1 neurons without synaptic activity; somatic action potentials, induced by backfiring the cells, were found to be… CONTINUE READING