Somatic TP53 Mutations in the Era of Genome Sequencing.


Amid the complexity of genetic alterations in human cancer, TP53 mutation appears as an almost invariant component, representing by far the most frequent genetic alteration overall. Compared with previous targeted sequencing studies, recent integrated genomics studies offer a less biased view of TP53 mutation patterns, revealing that >20% of mutations occur… (More)
DOI: 10.1101/cshperspect.a026179


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