Somatic KRAS mutations associated with a human nonmalignant syndrome of autoimmunity and abnormal leukocyte homeostasis.

@article{Niemela2011SomaticKM,
  title={Somatic KRAS mutations associated with a human nonmalignant syndrome of autoimmunity and abnormal leukocyte homeostasis.},
  author={Julie E. Niemela and Lianghao Lu and Thomas A. Fleisher and Joie N. Davis and Iusta Caminha and Marc D. Natter and Laurel A. Beer and Kennichi C. Dowdell and Stefania Pittaluga and Mark A. Raffeld and V Koneti Rao and Joao Bosco Oliveira},
  journal={Blood},
  year={2011},
  volume={117 10},
  pages={2883-6}
}
Somatic gain-of-function mutations in members of the RAS subfamily of small guanosine triphosphatases are found in > 30% of all human cancers. We recently described a syndrome of chronic nonmalignant lymphadenopathy, splenomegaly, and autoimmunity associated with a mutation in NRAS affecting hematopoietic cells, and initially we classified the disease as a variant of the autoimmune lymphoproliferative syndrome. Here, we demonstrate that somatic mutations in the related KRAS gene can also be… CONTINUE READING

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