Somatic Hypermutation in the Absence of DNA-Dependent Protein Kinase Catalytic Subunit (DNA-Pkcs) or Recombination-Activating Gene (Rag)1 Activity

@article{Bemark2000SomaticHI,
  title={Somatic Hypermutation in the Absence of DNA-Dependent Protein Kinase Catalytic Subunit (DNA-Pkcs) or Recombination-Activating Gene (Rag)1 Activity},
  author={Mats Bemark and Julian E Sale and Hye-Jung Kim and Claudia Berek and Ruth A. Cosgrove and Michael Neuberger},
  journal={The Journal of Experimental Medicine},
  year={2000},
  volume={192},
  pages={1509 - 1514}
}
Somatic hypermutation and isotype switch recombination occur in germinal center B cells, are linked to transcription, and are similarly affected by deficiency in MutS homologue (MSH)2. Class-switch recombination is abrogated by disruption of genes encoding components of the catalytic subunit of DNA-dependent protein kinase (DNA-PK(cs))/Ku complex and likely involves nonhomologous end joining (NHEJ). That somatic hypermutation might also be associated with end joining is suggested by its… CONTINUE READING
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The C-terminal conserved domain of DNA-PKcs, missing in the SCID mouse, is required for kinase activity

  • H. J. Beamish, R. Jessberger, R. A. Priestley, T. Blunt, B. Kysela, P. A. Jeggo
  • Nucleic Acids Res
  • 2000
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