Somatic Hypermutation, Transcription, and DNA Mismatch Repair

@article{Wiesendanger1998SomaticHT,
  title={Somatic Hypermutation, Transcription, and DNA Mismatch Repair},
  author={Margrit Wiesendanger and Matthew D. Scharff and Winfried Edelmann},
  journal={Cell},
  year={1998},
  volume={94},
  pages={415-418}
}
hypermutation, suggesting that cis-acting sequences outside the mutable region regulate and target mutation. However, almost nothing is known about the detailed molecular mechanisms or transacting proteins that are responsible for V-region hypermutation. Because the mutational process begins just downstream of the promoter and requires transcriptional en-hancers (Neuberger et al., 1998), it has been suggested Antibody diversity is generated through genetic and mo-that the initiation of… CONTINUE READING

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