Somatic Fas mutations in non-Hodgkin's lymphoma: association with extranodal disease and autoimmunity.

@article{Grnbaek1998SomaticFM,
  title={Somatic Fas mutations in non-Hodgkin's lymphoma: association with extranodal disease and autoimmunity.},
  author={Kirsten Gr\onbaek and P Straten and Elisabeth Methner Ralfkiaer and Vibeke Ahrenkiel and M K Andersen and Niels Ebbe Hansen and Jesper Zeuthen and Klaus Hou-Jensen and Per Guldberg},
  journal={Blood},
  year={1998},
  volume={92 9},
  pages={3018-24}
}
Fas (APO-1/CD95) is a cell-surface receptor involved in cell death signaling. Germline mutations in the Fas gene have been associated with autoimmune lymphoproliferative syndrome, and somatic Fas mutations have been found in multiple myeloma. We have examined the entire coding region and all splice sites of the Fas gene in 150 cases of non-Hodgkin's lymphoma. Overall, mutations were identified in 16 of the tumors (11%). Missense mutations within the death domain of the receptor were associated… CONTINUE READING
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Alterations of theMMAC1/PTEN gene in lymphoid malignancies

  • K Grønbæk, E Ralfkiær, J Zeuthen, K Hou-Jensen, P Guldberg
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