Somatic Cell Fusions Reveal Extensive Heterogeneity in Basal-like Breast Cancer.

@article{Su2015SomaticCF,
  title={Somatic Cell Fusions Reveal Extensive Heterogeneity in Basal-like Breast Cancer.},
  author={Ying Su and Ashim Subedee and Noga Bloushtain-Qimron and Virginia Savova and M. Krzystanek and Lewyn Li and Andriy Marusyk and Doris Priscilla Tabassum and Alexander Y. Zak and Mary Jo Flacker and Mengting Li and Jessica J Lin and Saraswati Sukumar and Hiromu Suzuki and Henry W. Long and Zoltan Szallasi and Alexander A. Gimelbrant and Reo Maruyama and Kornelia Polyak},
  journal={Cell reports},
  year={2015},
  volume={11 10},
  pages={
          1549-63
        }
}
Basal-like and luminal breast tumors have distinct clinical behavior and molecular profiles, yet the underlying mechanisms are poorly defined. To interrogate processes that determine these distinct phenotypes and their inheritance pattern, we generated somatic cell fusions and performed integrated genetic and epigenetic (DNA methylation and chromatin) profiling. We found that the basal-like trait is generally dominant and is largely defined by epigenetic repression of luminal transcription… CONTINUE READING

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