Somatic Cell Fusions Reveal Extensive Heterogeneity in Basal-like Breast Cancer.

@article{Su2015SomaticCF,
  title={Somatic Cell Fusions Reveal Extensive Heterogeneity in Basal-like Breast Cancer.},
  author={Y. Su and Ashim Subedee and N. Bloushtain-Qimron and Virginia Savova and M. Krzystanek and Lewyn Li and A. Marusyk and D. P. Tabassum and Alexander Y. Zak and Mary Jo Flacker and M. Li and J. Lin and S. Sukumar and H. Suzuki and H. Long and Z. Szallasi and A. Gimelbrant and R. Maruyama and K. Polyak},
  journal={Cell reports},
  year={2015},
  volume={11 10},
  pages={
          1549-63
        }
}
  • Y. Su, Ashim Subedee, +16 authors K. Polyak
  • Published 2015
  • Biology, Medicine
  • Cell reports
  • Basal-like and luminal breast tumors have distinct clinical behavior and molecular profiles, yet the underlying mechanisms are poorly defined. To interrogate processes that determine these distinct phenotypes and their inheritance pattern, we generated somatic cell fusions and performed integrated genetic and epigenetic (DNA methylation and chromatin) profiling. We found that the basal-like trait is generally dominant and is largely defined by epigenetic repression of luminal transcription… CONTINUE READING
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