Somatic Cell Fusions Reveal Extensive Heterogeneity in Basal-like Breast Cancer.
@article{Su2015SomaticCF, title={Somatic Cell Fusions Reveal Extensive Heterogeneity in Basal-like Breast Cancer.}, author={Y. Su and Ashim Subedee and N. Bloushtain-Qimron and Virginia Savova and M. Krzystanek and Lewyn Li and A. Marusyk and D. P. Tabassum and Alexander Y. Zak and Mary Jo Flacker and M. Li and J. Lin and S. Sukumar and H. Suzuki and H. Long and Z. Szallasi and A. Gimelbrant and R. Maruyama and K. Polyak}, journal={Cell reports}, year={2015}, volume={11 10}, pages={ 1549-63 } }
Basal-like and luminal breast tumors have distinct clinical behavior and molecular profiles, yet the underlying mechanisms are poorly defined. To interrogate processes that determine these distinct phenotypes and their inheritance pattern, we generated somatic cell fusions and performed integrated genetic and epigenetic (DNA methylation and chromatin) profiling. We found that the basal-like trait is generally dominant and is largely defined by epigenetic repression of luminal transcription… CONTINUE READING
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References
SHOWING 1-10 OF 46 REFERENCES
Epigenetic Regulation of Cell Type–Specific Expression Patterns in the Human Mammary Epithelium
- Biology, Medicine
- PLoS genetics
- 2011
- 78
- PDF
Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers
- Biology, Medicine
- Nature Medicine
- 2009
- 1,172
- PDF
The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups
- Biology, Medicine
- Nature
- 2012
- 3,529
- PDF
BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells.
- Biology, Medicine
- Cell stem cell
- 2010
- 596
BRCA1 regulates human mammary stem/progenitor cell fate
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 2008
- 444
- PDF
Deconstructing the molecular portraits of breast cancer
- Biology, Medicine
- Molecular oncology
- 2011
- 1,027
- PDF
Targets of extinction: identification of genes whose expression is repressed as a consequence of somatic fusion between cells representing basal and luminal mammary epithelial phenotypes.
- Biology, Medicine
- Journal of cell science
- 2000
- 11
- PDF
Novel role of Engrailed 1 as a prosurvival transcription factor in basal-like breast cancer and engineering of interference peptides block its oncogenic function
- Biology, Medicine
- Oncogene
- 2014
- 48
- PDF
Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies.
- Biology, Medicine
- The Journal of clinical investigation
- 2011
- 3,059
- PDF