Somatic Cell Fusions Reveal Extensive Heterogeneity in Basal-like Breast Cancer.

  title={Somatic Cell Fusions Reveal Extensive Heterogeneity in Basal-like Breast Cancer.},
  author={Y. Su and Ashim Subedee and N. Bloushtain-Qimron and Virginia Savova and M. Krzystanek and Lewyn Li and A. Marusyk and D. P. Tabassum and Alexander Y. Zak and Mary Jo Flacker and M. Li and J. Lin and S. Sukumar and H. Suzuki and H. Long and Z. Szallasi and A. Gimelbrant and R. Maruyama and K. Polyak},
  journal={Cell reports},
  volume={11 10},
  • Y. Su, Ashim Subedee, +16 authors K. Polyak
  • Published 2015
  • Biology, Medicine
  • Cell reports
  • Basal-like and luminal breast tumors have distinct clinical behavior and molecular profiles, yet the underlying mechanisms are poorly defined. To interrogate processes that determine these distinct phenotypes and their inheritance pattern, we generated somatic cell fusions and performed integrated genetic and epigenetic (DNA methylation and chromatin) profiling. We found that the basal-like trait is generally dominant and is largely defined by epigenetic repression of luminal transcription… CONTINUE READING
    49 Citations
    New Epigenetic Therapeutic Intervention for Metastatic Breast Cancer
    • PDF
    A novel subtype classification and risk of breast cancer by histone modification profiling
    • 17
    Delineating cellular heterogeneity and organization of breast cancer stem cells
    • PDF


    Comprehensive molecular portraits of human breast tumors
    • 6,097
    • PDF
    Epigenetic Regulation of Cell Type–Specific Expression Patterns in the Human Mammary Epithelium
    • 78
    • PDF
    Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers
    • 1,172
    • PDF
    BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells.
    • 596
    BRCA1 regulates human mammary stem/progenitor cell fate
    • 444
    • PDF
    Deconstructing the molecular portraits of breast cancer
    • 1,027
    • PDF
    Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies.
    • 3,059
    • PDF