Soma‐to‐germline feedback is implied by the extreme polymorphism at IGHV relative to MHC

@article{Steele2015SomatogermlineFI,
  title={Soma‐to‐germline feedback is implied by the extreme polymorphism at IGHV relative to MHC},
  author={Edward J. Steele and Sally S Lloyd},
  journal={BioEssays},
  year={2015},
  volume={37}
}
Soma‐to‐germline feedback is forbidden under the neo‐Darwinian paradigm. Nevertheless, there is a growing realization it occurs frequently in immunoglobulin (Ig) variable (V) region genes. This is a surprising development. It arises from a most unlikely source in light of the exposure of co‐author EJS to the haplotype data of RL Dawkins and others on the polymorphism of the Major Histocompatibility Complex, which is generally assumed to be the most polymorphic region in the genome (spanning ∼4… 
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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Darwin’s sub-cellular theory of inheritance: unknown or ignored?
TLDR
Although Weismann argued against the inheritance of acquired characters and Darwin’s Pangenesis, he recognized that BDarwin was the first to think out a theory of heredity which was worthy of the name of theory, for it was not merely an idea hastily suggested, but an attempt at elaborating a definite hypothesis.
Evidence of gene orthology and trans‐species polymorphism, but not of parallel evolution, despite high levels of concerted evolution in the major histocompatibility complex of flamingo species
TLDR
High sequence similarity between all species regardless of codon position is found, which is consistent with balancing selection maintaining TSP, as under this mechanism amino acid sites under pathogen‐mediated selection should be characterized by fewer synonymous codons than under parallel evolution.
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